Persons with high blood pressure who require medicine will be treated with FDA approved medicines for high blood pressure. Sexual function will be evaluated during this 28-week study. Women over the age of 50 who are postmenopausal and have high blood pressure might be eligible for this study. Patients who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

Patients with osteoarthritis or rheumatoid arthritis who have heart disease or who are at high risk for developing heart disease will be invited to participate to determine if the study medications are safe to use in patients with heart disease. Study drugs are FDA approved and patients will receive FDA approved study medications for a duration of 18-42 months. Patients who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

Often times, opioid drugs that are used commonly for pain can cause constipation and other abdominal symptoms.  This study will invite patients that have experienced constipation from the use of opioid drugs to participate.  In this trial, patients will receive a drug for 52 weeks that will relieve constipation without affecting how the opiod medication works on pain.  Patients who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

Several drug therapies are available after a patient has their first heart attack, but none have explored the role of inflammation in preventing another heart attack.  Patient who have had a heart attack in the past are invited to participate in this trial.  In this trial, patients will receive a drug that reduces inflammation over a period of approximately 36 months which may lower your risk for another heart attack.  Patients who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

Taking several medications for diabetes can be cumbersome.  Often times, these medications do not effectively lower blood sugar, and can cause weight gain and dangerously low blood sugar.  This study will offer patients who have type 2 diabetes a chance to recieve a combination medication for 6 months that lowers blood sugar and can avoid the hassle of taking multiple medications.  Patients who are currently taking 1 or 2 oral medications qualify and will receive study medication, lab tests, study-related care and physical examinations at no cost.

It is not uncommon to take multiple diabetes medications and still not be able to reach your blood sugar goals.  Insulin was developed to lower blood sugar in the same ways the body does, therefore, allowing for a more normal blood sugar level around mealtime.  This study will give patients a chance to control their blood sugar by using insulin once daily for 7 months.  Patients are invited to participate in this trial if they have not taken insulin before and are currently taking 1 or 2 oral diabetes medications.  Those who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

Currently available medications for osteoporosis are difficult to take which can lead to patients not taking them at all.  Newer drugs can be given once every 6 months and are effective in building strong bones.  Those patients that are postmenopausal and are already taking this new medication or about to start taking it will be asked to participate.  Patients who qualify will receive follow-up care at no cost.

High cholesterol can lead to severe heart disease and preventing it early on can be important to lowering your risk for a heart attack.  If you are not currently taking any medications for your cholesterol or have been taking your medication for less than 2 weeks, you will be eligible to participate.  The drug given during this trial will be dosed either once every 2 weeks or every 4 weeks.  Those who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

Patients who have diabetes have an increased risk of developing heart disease.  This study will invite patients who recently had a heart attack and are currently taking one or more diabetic medications to participate.  For a period of 2 years, patients will receive a medication that lowers their blood sugar and may lower their risk of another heart attack.  Those who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

Patients who have gout can often go into periods without feeling any symptoms.  It is important to start long term medications at that time to prevent future gout flares, more frequent attacks, and joint damage.  This study will invite patients who have gout that would like to prevent the reoccurence of painful flares.  Those who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost over a period of 20 weeks.

Currently, there are no medications that prevent or treat kidney injury despite the fact that it is common for the kidney to be damaged during cardiac surgery.  This study will test if a new drug can prevent kidney injury following a cardiac surgery procedure.  Those who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.

A heart attack is associated with significant problems including a reduced quality of life, other clinical problems, and even death.  This study will treat patients with a new medication that may reduce the risk of death following a heart procedure after a heart attack.  Those who qualify will receive study medication, lab tests, study-related care and physical examinations at no cost.